CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Identifieur interne : 000420 ( Main/Exploration ); précédent : 000419; suivant : 000421CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Auteurs : Paulina Bartuzi [Pays-Bas] ; Daniel D. Billadeau [États-Unis] ; Robert Favier [Pays-Bas] ; Shunxing Rong [États-Unis] ; Daphne Dekker [Pays-Bas] ; Alina Fedoseienko [Pays-Bas] ; Hille Fieten [Pays-Bas] ; Melinde Wijers [Pays-Bas] ; Johannes H. Levels [Pays-Bas] ; Nicolette Huijkman [Pays-Bas] ; Niels Kloosterhuis [Pays-Bas] ; Henk Van Der Molen [Pays-Bas] ; Gemma Brufau [Pays-Bas] ; Albert K. Groen [Pays-Bas] ; Alison M. Elliott [Canada] ; Jan Albert Kuivenhoven [Pays-Bas] ; Barbara Plecko [Autriche, Suisse] ; Gernot Grangl [Autriche] ; Julie Mcgaughran [Australie] ; Jay D. Horton [États-Unis] ; Ezra Burstein [États-Unis] ; Marten H. Hofker [Pays-Bas] ; Bart Van De Sluis [Pays-Bas]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function. We find that patients with X-linked intellectual disability caused by mutations in
Url:
DOI: 10.1038/ncomms10961
PubMed: 26965651
PubMed Central: 4792963
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000198
- to stream Pmc, to step Curation: 000198
- to stream Pmc, to step Checkpoint: 000155
- to stream Ncbi, to step Merge: 001E96
- to stream Ncbi, to step Curation: 001E96
- to stream Ncbi, to step Checkpoint: 001E96
- to stream Main, to step Merge: 000421
- to stream Main, to step Curation: 000420
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL</title><author><name sortKey="Bartuzi, Paulina" sort="Bartuzi, Paulina" uniqKey="Bartuzi P" first="Paulina" last="Bartuzi">Paulina Bartuzi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Billadeau, Daniel D" sort="Billadeau, Daniel D" uniqKey="Billadeau D" first="Daniel D." last="Billadeau">Daniel D. Billadeau</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic</institution>, 200 First Street Southwest, Rochester, Minnesota 55905, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, 200 First Street Southwest, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic</institution>, 200 First Street Southwest, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Favier, Robert" sort="Favier, Robert" uniqKey="Favier R" first="Robert" last="Favier">Robert Favier</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University</institution>, Yalelaan 108, 3584 CM Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rong, Shunxing" sort="Rong, Shunxing" uniqKey="Rong S" first="Shunxing" last="Rong">Shunxing Rong</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular Genetics, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dekker, Daphne" sort="Dekker, Daphne" uniqKey="Dekker D" first="Daphne" last="Dekker">Daphne Dekker</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fedoseienko, Alina" sort="Fedoseienko, Alina" uniqKey="Fedoseienko A" first="Alina" last="Fedoseienko">Alina Fedoseienko</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fieten, Hille" sort="Fieten, Hille" uniqKey="Fieten H" first="Hille" last="Fieten">Hille Fieten</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University</institution>, Yalelaan 108, 3584 CM Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wijers, Melinde" sort="Wijers, Melinde" uniqKey="Wijers M" first="Melinde" last="Wijers">Melinde Wijers</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Levels, Johannes H" sort="Levels, Johannes H" uniqKey="Levels J" first="Johannes H." last="Levels">Johannes H. Levels</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Vascular and Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huijkman, Nicolette" sort="Huijkman, Nicolette" uniqKey="Huijkman N" first="Nicolette" last="Huijkman">Nicolette Huijkman</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kloosterhuis, Niels" sort="Kloosterhuis, Niels" uniqKey="Kloosterhuis N" first="Niels" last="Kloosterhuis">Niels Kloosterhuis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Molen, Henk" sort="Van Der Molen, Henk" uniqKey="Van Der Molen H" first="Henk" last="Van Der Molen">Henk Van Der Molen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brufau, Gemma" sort="Brufau, Gemma" uniqKey="Brufau G" first="Gemma" last="Brufau">Gemma Brufau</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Pediatrics, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Groen, Albert K" sort="Groen, Albert K" uniqKey="Groen A" first="Albert K." last="Groen">Albert K. Groen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Pediatrics, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M." last="Elliott">Alison M. Elliott</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Medical Genetics, University of British Columbia</institution>, 4500 Oak Street, Vancouver, British Columbia,<country>Canada</country> V6H 3N1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuivenhoven, Jan Albert" sort="Kuivenhoven, Jan Albert" uniqKey="Kuivenhoven J" first="Jan Albert" last="Kuivenhoven">Jan Albert Kuivenhoven</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Plecko, Barbara" sort="Plecko, Barbara" uniqKey="Plecko B" first="Barbara" last="Plecko">Barbara Plecko</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz</institution>, Auenbruggerplatz 2, A-8036 Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Division of Child Neurology, University Children's Hospital</institution>, Steinwiesstrasse 75, CH-8032 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grangl, Gernot" sort="Grangl, Gernot" uniqKey="Grangl G" first="Gernot" last="Grangl">Gernot Grangl</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz</institution>, Auenbruggerplatz 2, A-8036 Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcgaughran, Julie" sort="Mcgaughran, Julie" uniqKey="Mcgaughran J" first="Julie" last="Mcgaughran">Julie Mcgaughran</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Genetic Health Queensland at the Royal Brisbane and Women's Hospital, Herston, University of Queensland</institution>, Herston, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a12"><institution>School of Medicine, University of Queensland</institution>, Herston, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horton, Jay D" sort="Horton, Jay D" uniqKey="Horton J" first="Jay D." last="Horton">Jay D. Horton</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular Genetics, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Internal Medicine, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burstein, Ezra" sort="Burstein, Ezra" uniqKey="Burstein E" first="Ezra" last="Burstein">Ezra Burstein</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Internal Medicine, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Molecular Biology, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofker, Marten H" sort="Hofker, Marten H" uniqKey="Hofker M" first="Marten H." last="Hofker">Marten H. Hofker</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van De Sluis, Bart" sort="Van De Sluis, Bart" uniqKey="Van De Sluis B" first="Bart" last="Van De Sluis">Bart Van De Sluis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26965651</idno><idno type="pmc">4792963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792963</idno><idno type="RBID">PMC:4792963</idno><idno type="doi">10.1038/ncomms10961</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000198</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000198</idno><idno type="wicri:Area/Pmc/Curation">000198</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000198</idno><idno type="wicri:Area/Pmc/Checkpoint">000155</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000155</idno><idno type="wicri:Area/Ncbi/Merge">001E96</idno><idno type="wicri:Area/Ncbi/Curation">001E96</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E96</idno><idno type="wicri:Area/Main/Merge">000421</idno><idno type="wicri:Area/Main/Curation">000420</idno><idno type="wicri:Area/Main/Exploration">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL</title><author><name sortKey="Bartuzi, Paulina" sort="Bartuzi, Paulina" uniqKey="Bartuzi P" first="Paulina" last="Bartuzi">Paulina Bartuzi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Billadeau, Daniel D" sort="Billadeau, Daniel D" uniqKey="Billadeau D" first="Daniel D." last="Billadeau">Daniel D. Billadeau</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic</institution>, 200 First Street Southwest, Rochester, Minnesota 55905, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, 200 First Street Southwest, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic</institution>, 200 First Street Southwest, Rochester, Minnesota 55905,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Favier, Robert" sort="Favier, Robert" uniqKey="Favier R" first="Robert" last="Favier">Robert Favier</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University</institution>, Yalelaan 108, 3584 CM Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rong, Shunxing" sort="Rong, Shunxing" uniqKey="Rong S" first="Shunxing" last="Rong">Shunxing Rong</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular Genetics, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dekker, Daphne" sort="Dekker, Daphne" uniqKey="Dekker D" first="Daphne" last="Dekker">Daphne Dekker</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fedoseienko, Alina" sort="Fedoseienko, Alina" uniqKey="Fedoseienko A" first="Alina" last="Fedoseienko">Alina Fedoseienko</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fieten, Hille" sort="Fieten, Hille" uniqKey="Fieten H" first="Hille" last="Fieten">Hille Fieten</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University</institution>, Yalelaan 108, 3584 CM Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wijers, Melinde" sort="Wijers, Melinde" uniqKey="Wijers M" first="Melinde" last="Wijers">Melinde Wijers</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Levels, Johannes H" sort="Levels, Johannes H" uniqKey="Levels J" first="Johannes H." last="Levels">Johannes H. Levels</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Vascular and Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam</institution>, Meibergdreef 9, 1105 AZ Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huijkman, Nicolette" sort="Huijkman, Nicolette" uniqKey="Huijkman N" first="Nicolette" last="Huijkman">Nicolette Huijkman</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kloosterhuis, Niels" sort="Kloosterhuis, Niels" uniqKey="Kloosterhuis N" first="Niels" last="Kloosterhuis">Niels Kloosterhuis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Molen, Henk" sort="Van Der Molen, Henk" uniqKey="Van Der Molen H" first="Henk" last="Van Der Molen">Henk Van Der Molen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brufau, Gemma" sort="Brufau, Gemma" uniqKey="Brufau G" first="Gemma" last="Brufau">Gemma Brufau</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Pediatrics, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Groen, Albert K" sort="Groen, Albert K" uniqKey="Groen A" first="Albert K." last="Groen">Albert K. Groen</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Pediatrics, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M." last="Elliott">Alison M. Elliott</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Medical Genetics, University of British Columbia</institution>, 4500 Oak Street, Vancouver, British Columbia,<country>Canada</country> V6H 3N1</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kuivenhoven, Jan Albert" sort="Kuivenhoven, Jan Albert" uniqKey="Kuivenhoven J" first="Jan Albert" last="Kuivenhoven">Jan Albert Kuivenhoven</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Plecko, Barbara" sort="Plecko, Barbara" uniqKey="Plecko B" first="Barbara" last="Plecko">Barbara Plecko</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz</institution>, Auenbruggerplatz 2, A-8036 Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Division of Child Neurology, University Children's Hospital</institution>, Steinwiesstrasse 75, CH-8032 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grangl, Gernot" sort="Grangl, Gernot" uniqKey="Grangl G" first="Gernot" last="Grangl">Gernot Grangl</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz</institution>, Auenbruggerplatz 2, A-8036 Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcgaughran, Julie" sort="Mcgaughran, Julie" uniqKey="Mcgaughran J" first="Julie" last="Mcgaughran">Julie Mcgaughran</name><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Genetic Health Queensland at the Royal Brisbane and Women's Hospital, Herston, University of Queensland</institution>, Herston, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a12"><institution>School of Medicine, University of Queensland</institution>, Herston, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horton, Jay D" sort="Horton, Jay D" uniqKey="Horton J" first="Jay D." last="Horton">Jay D. Horton</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular Genetics, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Internal Medicine, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burstein, Ezra" sort="Burstein, Ezra" uniqKey="Burstein E" first="Ezra" last="Burstein">Ezra Burstein</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Internal Medicine, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Molecular Biology, University of Texas Southwestern Medical Center</institution>, 5323 Harry Hines Boulevard, Dallas, Texas 75390,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofker, Marten H" sort="Hofker, Marten H" uniqKey="Hofker M" first="Marten H." last="Hofker">Marten H. Hofker</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van De Sluis, Bart" sort="Van De Sluis, Bart" uniqKey="Van De Sluis B" first="Bart" last="Van De Sluis">Bart Van De Sluis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen</institution>, Antonius Deusinglaan 1, 9713 AV Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function. We find that patients with X-linked intellectual disability caused by mutations in <italic>CCDC22</italic> are hypercholesterolaemic, and that COMMD1-deficient dogs and liver-specific <italic>Commd1</italic> knockout mice have elevated plasma LDL cholesterol levels. Furthermore, <italic>Commd1</italic> depletion results in mislocalization of LDLR, accompanied by decreased LDL uptake. Increased total plasma cholesterol levels are also seen in hepatic COMMD9-deficient mice. Inactivation of the CCC-associated WASH complex causes LDLR mislocalization, increased lysosomal degradation of LDLR and impaired LDL uptake. Furthermore, a mutation in the WASH component <italic>KIAA0196</italic> (strumpellin) is associated with hypercholesterolaemia in humans. Altogether, this study provides valuable insights into the mechanisms regulating cholesterol homeostasis and LDLR trafficking.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gomez, T S" uniqKey="Gomez T">T. S. Gomez</name></author><author><name sortKey="Billadeau, D D" uniqKey="Billadeau D">D. D. Billadeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harbour, M E" uniqKey="Harbour M">M. E. Harbour</name></author><author><name sortKey="Breusegem, S Y" uniqKey="Breusegem S">S. Y. Breusegem</name></author><author><name sortKey="Seaman, M N J" uniqKey="Seaman M">M. N. J. Seaman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seaman, M N J" uniqKey="Seaman M">M. N. J. Seaman</name></author><author><name sortKey="Gautreau, A" uniqKey="Gautreau A">A. Gautreau</name></author><author><name sortKey="Billadeau, D D" uniqKey="Billadeau D">D. D. Billadeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harbour, M E" uniqKey="Harbour M">M. E. Harbour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, D" uniqKey="Jia D">D. Jia</name></author><author><name sortKey="Gomez, T S" uniqKey="Gomez T">T. S. Gomez</name></author><author><name sortKey="Billadeau, D D" uniqKey="Billadeau D">D. D. Billadeau</name></author><author><name sortKey="Rosen, M K" uniqKey="Rosen M">M. K. Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helfer, E" uniqKey="Helfer E">E. Helfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cullen, P J" uniqKey="Cullen P">P. J. Cullen</name></author><author><name sortKey="Korswagen, H C" uniqKey="Korswagen H">H. C. Korswagen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips Krawczak, C A" uniqKey="Phillips Krawczak C">C. A. Phillips-Krawczak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, C L" uniqKey="Freeman C">C. L. Freeman</name></author><author><name sortKey="Hesketh, G" uniqKey="Hesketh G">G. Hesketh</name></author><author><name sortKey="Seaman, M N J" uniqKey="Seaman M">M. N. J. Seaman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burstein, E" uniqKey="Burstein E">E. Burstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Sluis, B" uniqKey="Van De Sluis B">B. van de Sluis</name></author><author><name sortKey="Rothuizen, J" uniqKey="Rothuizen J">J. Rothuizen</name></author><author><name sortKey="Pearson, P L" uniqKey="Pearson P">P. L. Pearson</name></author><author><name sortKey="Van Oost, B A" uniqKey="Van Oost B">B. A. van Oost</name></author><author><name sortKey="Wijmenga, C" uniqKey="Wijmenga C">C. Wijmenga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedoseienko, A" uniqKey="Fedoseienko A">A. Fedoseienko</name></author><author><name sortKey="Bartuzi, P" uniqKey="Bartuzi P">P. Bartuzi</name></author><author><name sortKey="Van De Sluis, B" uniqKey="Van De Sluis B">B. van de Sluis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Starokadomskyy, P" uniqKey="Starokadomskyy P">P. Starokadomskyy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porkka, K V" uniqKey="Porkka K">K. V. Porkka</name></author><author><name sortKey="Viikari, J S" uniqKey="Viikari J">J. S. Viikari</name></author><author><name sortKey="Ronnemaa, T" uniqKey="Ronnemaa T">T. Rönnemaa</name></author><author><name sortKey="Marniemi, J" uniqKey="Marniemi J">J. Marniemi</name></author><author><name sortKey="Akerblom, H K" uniqKey="Akerblom H">H. K. Akerblom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yip, P M" uniqKey="Yip P">P. M. Yip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiegman, A" uniqKey="Wiegman A">A. Wiegman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolanczyk, M" uniqKey="Kolanczyk M">M. Kolanczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Favier, R P" uniqKey="Favier R">R. P. Favier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailhache, E" uniqKey="Bailhache E">E. Bailhache</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huster, D" uniqKey="Huster D">D. Huster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fieten, H" uniqKey="Fieten H">H. Fieten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fieten, H" uniqKey="Fieten H">H. Fieten</name></author><author><name sortKey="Leegwater, P A J" uniqKey="Leegwater P">P. A. J. Leegwater</name></author><author><name sortKey="Watson, A L" uniqKey="Watson A">A. L. Watson</name></author><author><name sortKey="Rothuizen, J" uniqKey="Rothuizen J">J. Rothuizen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jessica Seessle" uniqKey="Jessica Seessle">Jessica Seessle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osono, Y" uniqKey="Osono Y">Y. Osono</name></author><author><name sortKey="Woollett, L A" uniqKey="Woollett L">L. A. Woollett</name></author><author><name sortKey="Herz, J" uniqKey="Herz J">J. Herz</name></author><author><name sortKey="Dietschy, J M" uniqKey="Dietschy J">J. M. Dietschy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vonk, W I M" uniqKey="Vonk W">W. I. M. Vonk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michaely, P" uniqKey="Michaely P">P. Michaely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinberg, F" uniqKey="Steinberg F">F. Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, T S" uniqKey="Gomez T">T. S. Gomez</name></author><author><name sortKey="Gorman, J A" uniqKey="Gorman J">J. A. Gorman</name></author><author><name sortKey="Artal Martinez De Narvajas, A" uniqKey="Artal Martinez De Narvajas A">A. Artal-Martinez de Narvajas</name></author><author><name sortKey="Koenig, A O" uniqKey="Koenig A">A. O. Koenig</name></author><author><name sortKey="Billadeau, D D" uniqKey="Billadeau D">D. D. Billadeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elliott, A M" uniqKey="Elliott A">A. M. Elliott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brautbar, A" uniqKey="Brautbar A">A. Brautbar</name></author><author><name sortKey="Ballantyne, C M" uniqKey="Ballantyne C">C. M. Ballantyne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, M S" uniqKey="Brown M">M. S. Brown</name></author><author><name sortKey="Goldstein, J L" uniqKey="Goldstein J">J. L. Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wijers, M" uniqKey="Wijers M">M. Wijers</name></author><author><name sortKey="Kuivenhoven, J A" uniqKey="Kuivenhoven J">J. A. Kuivenhoven</name></author><author><name sortKey="Van De Sluis, B" uniqKey="Van De Sluis B">B. van de Sluis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuchel, M" uniqKey="Cuchel M">M. Cuchel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zavodszky, E" uniqKey="Zavodszky E">E. Zavodszky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vilari O Guell, C" uniqKey="Vilari O Guell C">C. Vilariño-Güell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ropers, F" uniqKey="Ropers F">F. Ropers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Bot, S T" uniqKey="De Bot S">S. T. de Bot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valdmanis, P N" uniqKey="Valdmanis P">P. N. Valdmanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huttlin, E L" uniqKey="Huttlin E">E. L. Huttlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Temkin, P" uniqKey="Temkin P">P. Temkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghai, R" uniqKey="Ghai R">R. Ghai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockinger, W" uniqKey="Stockinger W">W. Stockinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burden, J J" uniqKey="Burden J">J. J. Burden</name></author><author><name sortKey="Sun, X M" uniqKey="Sun X">X.-M. Sun</name></author><author><name sortKey="Garcia, A B G" uniqKey="Garcia A">A. B. G. García</name></author><author><name sortKey="Soutar, A K" uniqKey="Soutar A">A. K. Soutar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farfan, P" uniqKey="Farfan P">P. Farfán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Kerkhof, P" uniqKey="Van Kerkhof P">P. van Kerkhof</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieti Inen, V" uniqKey="Pieti Inen V">V. Pietiäinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohlmann, A" uniqKey="Rohlmann A">A. Rohlmann</name></author><author><name sortKey="Gotthardt, M" uniqKey="Gotthardt M">M. Gotthardt</name></author><author><name sortKey="Willnow, T E" uniqKey="Willnow T">T. E. Willnow</name></author><author><name sortKey="Hammer, R E" uniqKey="Hammer R">R. E. Hammer</name></author><author><name sortKey="Herz, J" uniqKey="Herz J">J. Herz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartuzi, P" uniqKey="Bartuzi P">P. Bartuzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mao, X" uniqKey="Mao X">X. Mao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J H" uniqKey="Wu J">J.-H. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levels, J H M" uniqKey="Levels J">J. H. M. Levels</name></author><author><name sortKey="Lemaire, L C J M" uniqKey="Lemaire L">L. C. J. M. Lemaire</name></author><author><name sortKey="Van Den Ende, A E" uniqKey="Van Den Ende A">A. E. van den Ende</name></author><author><name sortKey="Van Deventer, S J H" uniqKey="Van Deventer S">S. J. H. van Deventer</name></author><author><name sortKey="Van Lanschot, J J B" uniqKey="Van Lanschot J">J. J. B. van Lanschot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vonk, W I M" uniqKey="Vonk W">W. I. M. Vonk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, C" uniqKey="Jones C">C. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lagace, T A" uniqKey="Lagace T">T. A. Lagace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Sluis, B" uniqKey="Van De Sluis B">B. van de Sluis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, C" uniqKey="Jones C">C. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maxwell, K N" uniqKey="Maxwell K">K. N. Maxwell</name></author><author><name sortKey="Breslow, J L" uniqKey="Breslow J">J. L. Breslow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maxwell, K N" uniqKey="Maxwell K">K. N. Maxwell</name></author><author><name sortKey="Fisher, E A" uniqKey="Fisher E">E. A. Fisher</name></author><author><name sortKey="Breslow, J L" uniqKey="Breslow J">J. L. Breslow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zelcer, N" uniqKey="Zelcer N">N. Zelcer</name></author><author><name sortKey="Hong, C" uniqKey="Hong C">C. Hong</name></author><author><name sortKey="Boyadjian, R" uniqKey="Boyadjian R">R. Boyadjian</name></author><author><name sortKey="Tontonoz, P" uniqKey="Tontonoz P">P. Tontonoz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derivery, E" uniqKey="Derivery E">E. Derivery</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Canada</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Bartuzi, Paulina" sort="Bartuzi, Paulina" uniqKey="Bartuzi P" first="Paulina" last="Bartuzi">Paulina Bartuzi</name></noRegion><name sortKey="Brufau, Gemma" sort="Brufau, Gemma" uniqKey="Brufau G" first="Gemma" last="Brufau">Gemma Brufau</name><name sortKey="Dekker, Daphne" sort="Dekker, Daphne" uniqKey="Dekker D" first="Daphne" last="Dekker">Daphne Dekker</name><name sortKey="Favier, Robert" sort="Favier, Robert" uniqKey="Favier R" first="Robert" last="Favier">Robert Favier</name><name sortKey="Fedoseienko, Alina" sort="Fedoseienko, Alina" uniqKey="Fedoseienko A" first="Alina" last="Fedoseienko">Alina Fedoseienko</name><name sortKey="Fieten, Hille" sort="Fieten, Hille" uniqKey="Fieten H" first="Hille" last="Fieten">Hille Fieten</name><name sortKey="Groen, Albert K" sort="Groen, Albert K" uniqKey="Groen A" first="Albert K." last="Groen">Albert K. Groen</name><name sortKey="Hofker, Marten H" sort="Hofker, Marten H" uniqKey="Hofker M" first="Marten H." last="Hofker">Marten H. Hofker</name><name sortKey="Huijkman, Nicolette" sort="Huijkman, Nicolette" uniqKey="Huijkman N" first="Nicolette" last="Huijkman">Nicolette Huijkman</name><name sortKey="Kloosterhuis, Niels" sort="Kloosterhuis, Niels" uniqKey="Kloosterhuis N" first="Niels" last="Kloosterhuis">Niels Kloosterhuis</name><name sortKey="Kuivenhoven, Jan Albert" sort="Kuivenhoven, Jan Albert" uniqKey="Kuivenhoven J" first="Jan Albert" last="Kuivenhoven">Jan Albert Kuivenhoven</name><name sortKey="Levels, Johannes H" sort="Levels, Johannes H" uniqKey="Levels J" first="Johannes H." last="Levels">Johannes H. Levels</name><name sortKey="Van De Sluis, Bart" sort="Van De Sluis, Bart" uniqKey="Van De Sluis B" first="Bart" last="Van De Sluis">Bart Van De Sluis</name><name sortKey="Van Der Molen, Henk" sort="Van Der Molen, Henk" uniqKey="Van Der Molen H" first="Henk" last="Van Der Molen">Henk Van Der Molen</name><name sortKey="Wijers, Melinde" sort="Wijers, Melinde" uniqKey="Wijers M" first="Melinde" last="Wijers">Melinde Wijers</name></country><country name="États-Unis"><noRegion><name sortKey="Billadeau, Daniel D" sort="Billadeau, Daniel D" uniqKey="Billadeau D" first="Daniel D." last="Billadeau">Daniel D. Billadeau</name></noRegion><name sortKey="Billadeau, Daniel D" sort="Billadeau, Daniel D" uniqKey="Billadeau D" first="Daniel D." last="Billadeau">Daniel D. Billadeau</name><name sortKey="Burstein, Ezra" sort="Burstein, Ezra" uniqKey="Burstein E" first="Ezra" last="Burstein">Ezra Burstein</name><name sortKey="Burstein, Ezra" sort="Burstein, Ezra" uniqKey="Burstein E" first="Ezra" last="Burstein">Ezra Burstein</name><name sortKey="Horton, Jay D" sort="Horton, Jay D" uniqKey="Horton J" first="Jay D." last="Horton">Jay D. Horton</name><name sortKey="Horton, Jay D" sort="Horton, Jay D" uniqKey="Horton J" first="Jay D." last="Horton">Jay D. Horton</name><name sortKey="Rong, Shunxing" sort="Rong, Shunxing" uniqKey="Rong S" first="Shunxing" last="Rong">Shunxing Rong</name></country><country name="Canada"><noRegion><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M." last="Elliott">Alison M. Elliott</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Plecko, Barbara" sort="Plecko, Barbara" uniqKey="Plecko B" first="Barbara" last="Plecko">Barbara Plecko</name></noRegion><name sortKey="Grangl, Gernot" sort="Grangl, Gernot" uniqKey="Grangl G" first="Gernot" last="Grangl">Gernot Grangl</name></country><country name="Suisse"><noRegion><name sortKey="Plecko, Barbara" sort="Plecko, Barbara" uniqKey="Plecko B" first="Barbara" last="Plecko">Barbara Plecko</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mcgaughran, Julie" sort="Mcgaughran, Julie" uniqKey="Mcgaughran J" first="Julie" last="Mcgaughran">Julie Mcgaughran</name></noRegion><name sortKey="Mcgaughran, Julie" sort="Mcgaughran, Julie" uniqKey="Mcgaughran J" first="Julie" last="Mcgaughran">Julie Mcgaughran</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000420 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000420 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4792963
|texte= CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26965651" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |